Drug interactions
Duvelisib + Ketamine
Severity: Moderate
Duvelisib and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and raises exposure to sensitive CYP3A4 substrates. Ketamine is partly cleared by CYP3A4, so its levels and effects may increase, particularly with oral dosing.
What this interaction means in plain words
Duvelisib and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Ketamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated ketamine metabolism by duvelisib.
What to do
Consider a lower ketamine dose and monitor for excess sedation, hallucinations and hemodynamic changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Ketamine?
MediHelp rates the interaction as moderate. Duvelisib and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor and raises exposure to sensitive CYP3A4 substrates. Ketamine is partly cleared by CYP3A4, so its levels and effects may increase, particularly with oral dosing.
How serious is the interaction between Duvelisib and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower ketamine dose and monitor for excess sedation, hallucinations and hemodynamic changes.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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