Drug interactions
Efavirenz + Eribulin
Severity: Moderate
Efavirenz and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so the combination may increase the risk of ventricular arrhythmia, particularly in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Efavirenz and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Eribulin belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Obtain an ECG before starting and periodically during therapy, and correct potassium and magnesium. Consider an alternative antiretroviral if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Efavirenz with Eribulin?
MediHelp rates the interaction as moderate. Efavirenz and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so the combination may increase the risk of ventricular arrhythmia, particularly in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Efavirenz and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting and periodically during therapy, and correct potassium and magnesium. Consider an alternative antiretroviral if the QTc becomes prolonged.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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