Drug interactions
Efavirenz + Etrasimod
Severity: Moderate
Efavirenz and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may affect etrasimod exposure through effects on several metabolic pathways. Etrasimod relies on CYP2C8, CYP2C9 and CYP3A4, and combined enzyme changes could alter exposure unpredictably.
What this interaction means in plain words
Efavirenz and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Efavirenz has mixed effects on CYP2C9 and CYP3A4, pathways which clear etrasimod, though the net effect is not clearly established.
What to do
Consider an alternative antiretroviral where possible. If used together, monitor for etrasimod adverse effects such as bradycardia and for therapeutic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Efavirenz with Etrasimod?
MediHelp rates the interaction as moderate. Efavirenz and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may affect etrasimod exposure through effects on several metabolic pathways. Etrasimod relies on CYP2C8, CYP2C9 and CYP3A4, and combined enzyme changes could alter exposure unpredictably.
How serious is the interaction between Efavirenz and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiretroviral where possible. If used together, monitor for etrasimod adverse effects such as bradycardia and for therapeutic response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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