Drug interactions
Efavirenz + Fludrocortisone
Severity: Moderate
Efavirenz and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may speed up the metabolism of fludrocortisone and reduce its mineralocorticoid effect. Patients with adrenal insufficiency could have inadequate replacement.
What this interaction means in plain words
Efavirenz and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Fludrocortisone belongs to Endocrine.
Why it happens
CYP3A4 induction by efavirenz increases fludrocortisone clearance.
What to do
Monitor blood pressure, serum sodium and potassium, and symptoms of adrenal insufficiency. Increase the fludrocortisone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Efavirenz with Fludrocortisone?
MediHelp rates the interaction as moderate. Efavirenz and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may speed up the metabolism of fludrocortisone and reduce its mineralocorticoid effect. Patients with adrenal insufficiency could have inadequate replacement.
How serious is the interaction between Efavirenz and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum sodium and potassium, and symptoms of adrenal insufficiency. Increase the fludrocortisone dose if needed.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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