Drug interactions
Efavirenz + Flurbiprofen
Severity: Minor
Efavirenz and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is a mixed CYP inducer and may also inhibit CYP2C9 in vitro, so its effect on flurbiprofen exposure is uncertain. A clinically important change in flurbiprofen levels has not been well demonstrated.
What this interaction means in plain words
Efavirenz and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Possible modulation of CYP2C9-mediated flurbiprofen metabolism by efavirenz; the net direction of effect is not established.
What to do
No empiric dose adjustment is needed; monitor for NSAID adverse effects or reduced analgesic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Flurbiprofen?
MediHelp rates the interaction as minor. Efavirenz and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz is a mixed CYP inducer and may also inhibit CYP2C9 in vitro, so its effect on flurbiprofen exposure is uncertain. A clinically important change in flurbiprofen levels has not been well demonstrated.
How serious is the interaction between Efavirenz and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose adjustment is needed; monitor for NSAID adverse effects or reduced analgesic response.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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