Drug interactions
Efavirenz + Fluticasone-salmeterol
Severity: Moderate
Efavirenz and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salmeterol and efavirenz can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmia, especially in patients with other risk factors. The effect is generally modest at usual inhaled salmeterol doses.
What this interaction means in plain words
Efavirenz and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Check baseline ECG and correct hypokalemia or hypomagnesemia in patients with QT risk factors. Avoid exceeding the recommended salmeterol dose and counsel patients to report palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Efavirenz and Fluticasone-salmeterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Efavirenz and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salmeterol and efavirenz can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmia, especially in patients with other risk factors. The effect is generally modest at usual inhaled salmeterol doses.
How serious is the interaction between Efavirenz and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct hypokalemia or hypomagnesemia in patients with QT risk factors. Avoid exceeding the recommended salmeterol dose and counsel patients to report palpitations or syncope.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
