Drug interactions
Efavirenz + Fluvastatin
Severity: Minor
Efavirenz and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may alter fluvastatin exposure, but the direction and size of the effect are uncertain. Efavirenz generally lowers concentrations of statins metabolised by CYP3A4, and fluvastatin is mainly handled by CYP2C9.
What this interaction means in plain words
Efavirenz and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Fluvastatin belongs to Cardiovascular.
Why it happens
Possible effect of efavirenz on CYP2C9-mediated fluvastatin metabolism; the mechanism is not well established.
What to do
Monitor lipid response and muscle symptoms. Adjust the fluvastatin dose according to lipid targets.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Frequently asked questions
Can I take Efavirenz with Fluvastatin?
MediHelp rates the interaction as minor. Efavirenz and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz may alter fluvastatin exposure, but the direction and size of the effect are uncertain. Efavirenz generally lowers concentrations of statins metabolised by CYP3A4, and fluvastatin is mainly handled by CYP2C9.
How serious is the interaction between Efavirenz and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and muscle symptoms. Adjust the fluvastatin dose according to lipid targets.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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