Drug interactions
Efavirenz + Isosorbide dinitrate
Severity: Minor
Efavirenz and Isosorbide dinitrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz might reduce isosorbide dinitrate exposure. The clinical importance is likely small because nitrate clearance is mostly non-CYP.
What this interaction means in plain words
Efavirenz and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Isosorbide dinitrate belongs to Cardiovascular.
Why it happens
Possible CYP3A4 induction; the mechanism is not well established for this nitrate.
What to do
Monitor angina control and blood pressure. Adjust the nitrate dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Frequently asked questions
Can I take Efavirenz with Isosorbide dinitrate?
MediHelp rates the interaction as minor. Efavirenz and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz might reduce isosorbide dinitrate exposure. The clinical importance is likely small because nitrate clearance is mostly non-CYP.
How serious is the interaction between Efavirenz and Isosorbide dinitrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor angina control and blood pressure. Adjust the nitrate dose if response is reduced.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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