Drug interactions
Efavirenz + Isosorbide mononitrate
Severity: Minor
Efavirenz and Isosorbide mononitrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is predicted to have little effect on isosorbide mononitrate, which is metabolised mainly by denitration and glucuronidation. Any reduction in effect is likely minimal.
What this interaction means in plain words
Efavirenz and Isosorbide mononitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Isosorbide mononitrate belongs to Cardiovascular.
Why it happens
Theoretical CYP3A4 induction; the mechanism is not established for this drug.
What to do
No routine adjustment is needed. Review angina control if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Frequently asked questions
Can I take Efavirenz with Isosorbide mononitrate?
MediHelp rates the interaction as minor. Efavirenz and Isosorbide mononitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz is predicted to have little effect on isosorbide mononitrate, which is metabolised mainly by denitration and glucuronidation. Any reduction in effect is likely minimal.
How serious is the interaction between Efavirenz and Isosorbide mononitrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Review angina control if symptoms worsen.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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