Drug interactions
Efavirenz + Metformin-repaglinide
Severity: Moderate
Efavirenz and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4 and CYP2B6 and may lower repaglinide concentrations, reducing its glucose-lowering effect. The magnitude is uncertain and variable between patients.
What this interaction means in plain words
Efavirenz and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Metformin-repaglinide belongs to Endocrine.
Why it happens
Induction of CYP3A4-mediated metabolism of repaglinide.
What to do
Monitor blood glucose after starting or stopping efavirenz and adjust the repaglinide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Efavirenz and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4 and CYP2B6 and may lower repaglinide concentrations, reducing its glucose-lowering effect. The magnitude is uncertain and variable between patients.
How serious is the interaction between Efavirenz and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping efavirenz and adjust the repaglinide dose as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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