Drug interactions
Efavirenz + Nateglinide
Severity: Minor
Efavirenz and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide is metabolized by CYP2C9 and CYP3A4. Efavirenz has variable effects on these enzymes, and a clinically important rise in nateglinide is not well established.
What this interaction means in plain words
Efavirenz and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Nateglinide belongs to Endocrine.
Why it happens
Efavirenz may alter CYP2C9 and CYP3A4 activity, but the direction and size of the effect are not well established.
What to do
No empiric dose change is needed. Monitor blood glucose when starting or stopping efavirenz and adjust nateglinide if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Efavirenz with Nateglinide?
MediHelp rates the interaction as minor. Efavirenz and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nateglinide is metabolized by CYP2C9 and CYP3A4. Efavirenz has variable effects on these enzymes, and a clinically important rise in nateglinide is not well established.
How serious is the interaction between Efavirenz and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor blood glucose when starting or stopping efavirenz and adjust nateglinide if needed.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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