Drug interactions
Efavirenz + Ofloxacin
Severity: Moderate
Efavirenz and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can prolong the QT interval, particularly at higher exposures, and ofloxacin may add a small further effect. Risk is higher with hypokalemia, bradycardia, or other QT-prolonging drugs.
What this interaction means in plain words
Efavirenz and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization.
What to do
Correct electrolyte disturbances and obtain an ECG in patients with additional QT risk factors. Consider a different antibiotic if the QTc is already prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Ofloxacin?
MediHelp rates the interaction as moderate. Efavirenz and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can prolong the QT interval, particularly at higher exposures, and ofloxacin may add a small further effect. Risk is higher with hypokalemia, bradycardia, or other QT-prolonging drugs.
How serious is the interaction between Efavirenz and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolyte disturbances and obtain an ECG in patients with additional QT risk factors. Consider a different antibiotic if the QTc is already prolonged.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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