Drug interactions
Efavirenz + Pantoprazole
Severity: Minor
Efavirenz and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may modestly alter pantoprazole exposure through effects on hepatic drug-metabolizing enzymes. The effect is not well characterized and is unlikely to change acid suppression in a meaningful way.
What this interaction means in plain words
Efavirenz and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Efavirenz has mixed inducing and inhibiting effects on CYP enzymes, which may change CYP2C19-mediated pantoprazole metabolism; the direction and size of the effect are not firmly established.
What to do
No routine adjustment is needed. Reassess if the patient has a poor response to acid suppression or unexpected adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Efavirenz with Pantoprazole?
MediHelp rates the interaction as minor. Efavirenz and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz may modestly alter pantoprazole exposure through effects on hepatic drug-metabolizing enzymes. The effect is not well characterized and is unlikely to change acid suppression in a meaningful way.
How serious is the interaction between Efavirenz and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Reassess if the patient has a poor response to acid suppression or unexpected adverse effects.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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