Drug interactions
Efavirenz + Sorafenib
Severity: Moderate
Efavirenz and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may modestly lower sorafenib exposure through CYP3A4 induction, and both drugs can prolong the QT interval. The combination could reduce efficacy and add to arrhythmia risk.
What this interaction means in plain words
Efavirenz and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
Efavirenz induces CYP3A4 metabolism of sorafenib and both agents have additive QT effects.
What to do
Monitor ECG and electrolytes and assess tumour response. Consider a non-inducing antiretroviral if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Efavirenz with Sorafenib?
MediHelp rates the interaction as moderate. Efavirenz and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may modestly lower sorafenib exposure through CYP3A4 induction, and both drugs can prolong the QT interval. The combination could reduce efficacy and add to arrhythmia risk.
How serious is the interaction between Efavirenz and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and assess tumour response. Consider a non-inducing antiretroviral if feasible.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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