Drug interactions
Efavirenz + Sotorasib
Severity: Major
Efavirenz and Sotorasib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce sotorasib concentrations through enzyme induction. Lower exposure may compromise the anticancer efficacy of sotorasib.
What this interaction means in plain words
Efavirenz and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Sotorasib belongs to Oncology.
Why it happens
Efavirenz induces CYP3A4, increasing the metabolism of sotorasib.
What to do
Avoid concurrent use and switch to an antiretroviral without CYP3A4 induction, such as dolutegravir or a boosted-free alternative. Monitor tumor response if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Efavirenz with Sotorasib?
MediHelp rates the interaction as major. Efavirenz and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz may reduce sotorasib concentrations through enzyme induction. Lower exposure may compromise the anticancer efficacy of sotorasib.
How serious is the interaction between Efavirenz and Sotorasib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and switch to an antiretroviral without CYP3A4 induction, such as dolutegravir or a boosted-free alternative. Monitor tumor response if it cannot be avoided.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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