Drug interactions
Efavirenz + Trabectedin
Severity: Moderate
Efavirenz and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce trabectedin exposure and lessen its anticancer effect. Strong CYP3A inducers are best avoided with trabectedin.
What this interaction means in plain words
Efavirenz and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Trabectedin belongs to Oncology.
Why it happens
Efavirenz induces CYP3A4, the main enzyme metabolizing trabectedin.
What to do
Prefer a non-inducing antiretroviral during trabectedin therapy. If it cannot be avoided, monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Trabectedin
Frequently asked questions
Can I take Efavirenz with Trabectedin?
MediHelp rates the interaction as moderate. Efavirenz and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may reduce trabectedin exposure and lessen its anticancer effect. Strong CYP3A inducers are best avoided with trabectedin.
How serious is the interaction between Efavirenz and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiretroviral during trabectedin therapy. If it cannot be avoided, monitor tumor response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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