Drug interactions
Efavirenz + Triptorelin
Severity: Moderate
Efavirenz and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can prolong the QT interval, and androgen deprivation therapy such as triptorelin may also lengthen QT. Used together they may add to the risk of arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Efavirenz and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Triptorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation: efavirenz directly, and triptorelin through testosterone suppression.
What to do
Obtain a baseline ECG and repeat it during treatment in patients with cardiac disease or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Triptorelin
Frequently asked questions
Can I take Efavirenz with Triptorelin?
MediHelp rates the interaction as moderate. Efavirenz and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can prolong the QT interval, and androgen deprivation therapy such as triptorelin may also lengthen QT. Used together they may add to the risk of arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Efavirenz and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it during treatment in patients with cardiac disease or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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