Drug interactions
Efavirenz + Vincristine
Severity: Moderate
Efavirenz and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower vincristine concentrations by inducing its metabolism, which could reduce efficacy. The effect is not well quantified, though it can also change the neurotoxicity profile.
What this interaction means in plain words
Efavirenz and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Vincristine belongs to Oncology.
Why it happens
Efavirenz induces CYP3A4, which is the main route of vincristine clearance.
What to do
Monitor treatment response and neurotoxicity. Consider an antiretroviral regimen without enzyme induction during vincristine-based chemotherapy when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Efavirenz with Vincristine?
MediHelp rates the interaction as moderate. Efavirenz and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower vincristine concentrations by inducing its metabolism, which could reduce efficacy. The effect is not well quantified, though it can also change the neurotoxicity profile.
How serious is the interaction between Efavirenz and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and neurotoxicity. Consider an antiretroviral regimen without enzyme induction during vincristine-based chemotherapy when possible.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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