Drug interactions
Efavirenz + Vinorelbine
Severity: Moderate
Efavirenz and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce vinorelbine exposure through enzyme induction, potentially decreasing its anticancer effect. The size of the effect is not well defined.
What this interaction means in plain words
Efavirenz and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Vinorelbine belongs to Oncology.
Why it happens
Efavirenz induces CYP3A4, which metabolizes vinorelbine.
What to do
Monitor clinical response and blood counts. Consider an alternative antiretroviral lacking CYP3A4 induction if efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Efavirenz with Vinorelbine?
MediHelp rates the interaction as moderate. Efavirenz and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may reduce vinorelbine exposure through enzyme induction, potentially decreasing its anticancer effect. The size of the effect is not well defined.
How serious is the interaction between Efavirenz and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and blood counts. Consider an alternative antiretroviral lacking CYP3A4 induction if efficacy is a concern.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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