Drug interactions
Efgartigimod / hyaluronidase sc + Guselkumab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Guselkumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor and lowers IgG levels, which may reduce guselkumab concentrations because it is an IgG antibody. Clinical effect is theoretical.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Guselkumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
FcRn blockade by efgartigimod increases the catabolism of IgG monoclonal antibodies such as guselkumab.
What to do
Monitor for loss of guselkumab efficacy; if it is lost, reassess the need for both therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Efgartigimod / hyaluronidase sc and Guselkumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Guselkumab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Guselkumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor and lowers IgG levels, which may reduce guselkumab concentrations because it is an IgG antibody. Clinical effect is theoretical.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Guselkumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of guselkumab efficacy; if it is lost, reassess the need for both therapies.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
