Drug interactions
Efgartigimod / hyaluronidase sc + Ustekinumab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor, which normally recycles IgG antibodies, and so accelerates IgG catabolism. Ustekinumab is an IgG1 monoclonal antibody, so its serum levels and efficacy could fall during treatment. The magnitude of the effect is not well characterized.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Efgartigimod blocks FcRn-mediated IgG recycling, which may increase clearance of IgG-based drugs such as ustekinumab.
What to do
Monitor disease control in the underlying inflammatory condition during efgartigimod therapy. Consider checking ustekinumab response and adjusting therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Ustekinumab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor, which normally recycles IgG antibodies, and so accelerates IgG catabolism. Ustekinumab is an IgG1 monoclonal antibody, so its serum levels and efficacy could fall during treatment. The magnitude of the effect is not well characterized.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease control in the underlying inflammatory condition during efgartigimod therapy. Consider checking ustekinumab response and adjusting therapy if control is lost.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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