Drug interactions
Elacestrant + Isoniazid
Severity: Moderate
Elacestrant and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and increase elacestrant exposure, possibly worsening nausea, dyslipidemia and musculoskeletal effects.
What this interaction means in plain words
Elacestrant and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, which is the main metabolic pathway of elacestrant.
What to do
Monitor for adverse effects and lipid levels. Consider an alternative to isoniazid if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Isoniazid?
MediHelp rates the interaction as moderate. Elacestrant and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may inhibit CYP3A4 and increase elacestrant exposure, possibly worsening nausea, dyslipidemia and musculoskeletal effects.
How serious is the interaction between Elacestrant and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and lipid levels. Consider an alternative to isoniazid if feasible.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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