Drug interactions
Elacestrant + Methotrexate
Severity: Moderate
Elacestrant and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant inhibits BCRP in vitro, and methotrexate is a BCRP substrate. Methotrexate exposure could rise, increasing the risk of myelosuppression, mucositis and hepatotoxicity.
What this interaction means in plain words
Elacestrant and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Methotrexate belongs to Oncology.
Why it happens
Inhibition of BCRP-mediated efflux may reduce methotrexate elimination.
What to do
Monitor blood counts and liver and renal function, and watch for methotrexate toxicity. Reduce the methotrexate dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Methotrexate?
MediHelp rates the interaction as moderate. Elacestrant and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant inhibits BCRP in vitro, and methotrexate is a BCRP substrate. Methotrexate exposure could rise, increasing the risk of myelosuppression, mucositis and hepatotoxicity.
How serious is the interaction between Elacestrant and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver and renal function, and watch for methotrexate toxicity. Reduce the methotrexate dose if toxicity appears.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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