Drug interactions
Elbasvir / grazoprevir + Mifepristone
Severity: Moderate
Elbasvir / grazoprevir and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase exposure to elbasvir and grazoprevir. Higher grazoprevir levels are linked to ALT elevations.
What this interaction means in plain words
Elbasvir / grazoprevir and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by mifepristone reduces clearance of the antivirals.
What to do
Monitor liver enzymes during treatment. Consider an alternative regimen if hepatotoxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Elbasvir / grazoprevir with Mifepristone?
MediHelp rates the interaction as moderate. Elbasvir / grazoprevir and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase exposure to elbasvir and grazoprevir. Higher grazoprevir levels are linked to ALT elevations.
How serious is the interaction between Elbasvir / grazoprevir and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes during treatment. Consider an alternative regimen if hepatotoxicity appears.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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