Drug interactions
Elbasvir / grazoprevir + Simvastatin
Severity: Moderate
Elbasvir / grazoprevir and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elbasvir/grazoprevir can raise simvastatin exposure and increase the risk of myopathy. Statin dosing should be kept low during the course of therapy.
What this interaction means in plain words
Elbasvir / grazoprevir and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Grazoprevir inhibits OATP1B1/3 and possibly intestinal BCRP and CYP3A4, increasing simvastatin concentrations.
What to do
Use the lowest effective simvastatin dose, or temporarily hold it or switch to another statin during the short HCV treatment. Monitor for muscle pain and weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Elbasvir / grazoprevir with Simvastatin?
MediHelp rates the interaction as moderate. Elbasvir / grazoprevir and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elbasvir/grazoprevir can raise simvastatin exposure and increase the risk of myopathy. Statin dosing should be kept low during the course of therapy.
How serious is the interaction between Elbasvir / grazoprevir and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective simvastatin dose, or temporarily hold it or switch to another statin during the short HCV treatment. Monitor for muscle pain and weakness.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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