Drug interactions
Elivaldogene autotemcel + Pneumococcal vaccine 13-valent
Severity: Moderate
Elivaldogene autotemcel and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elivaldogene autotemcel is given after myeloablative conditioning, leaving a period of immune compromise in which vaccine responses are unreliable. Safety and effectiveness of vaccination around this treatment have not been studied.
What this interaction means in plain words
Elivaldogene autotemcel and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Myeloablative conditioning and hematopoietic reconstitution impair immune response to vaccination.
What to do
Give childhood vaccines, including pneumococcal, before conditioning where feasible, avoiding the 6 weeks before it. Defer vaccination until hematologic recovery after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Elivaldogene autotemcel with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Elivaldogene autotemcel and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elivaldogene autotemcel is given after myeloablative conditioning, leaving a period of immune compromise in which vaccine responses are unreliable. Safety and effectiveness of vaccination around this treatment have not been studied.
How serious is the interaction between Elivaldogene autotemcel and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give childhood vaccines, including pneumococcal, before conditioning where feasible, avoiding the 6 weeks before it. Defer vaccination until hematologic recovery after treatment.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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