Drug interactions
Eltrombopag + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Eltrombopag and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP1A2 inhibitor and could slightly increase eltrombopag exposure. The clinical effect is expected to be small. Eltrombopag also carries a thrombotic risk, and combined hormonal contraceptives add to venous thromboembolism risk.
What this interaction means in plain words
Eltrombopag and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
Possible weak CYP1A2 inhibition by ethinyl estradiol, plus additive prothrombotic effects.
What to do
Monitor platelet counts and for signs of thrombosis; consider a progestin-only or non-hormonal contraceptive in patients with thrombotic risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Eltrombopag and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinyl estradiol is a weak CYP1A2 inhibitor and could slightly increase eltrombopag exposure. The clinical effect is expected to be small. Eltrombopag also carries a thrombotic risk, and combined hormonal contraceptives add to venous thromboembolism risk.
How serious is the interaction between Eltrombopag and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and for signs of thrombosis; consider a progestin-only or non-hormonal contraceptive in patients with thrombotic risk factors.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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