Drug interactions
Eltrombopag + Ethinylestradiol
Severity: Moderate
Eltrombopag and Ethinylestradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol is a weak CYP1A2 inhibitor, and eltrombopag is partly cleared by CYP1A2. A small rise in eltrombopag exposure is possible. Estrogens also raise thrombotic risk, which adds to the thrombotic risk of eltrombopag.
What this interaction means in plain words
Eltrombopag and Ethinylestradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethinylestradiol may inhibit CYP1A2-mediated eltrombopag metabolism.
What to do
Monitor platelet counts and liver tests. Consider non-estrogen contraception in patients with additional thrombotic risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Ethinylestradiol?
MediHelp rates the interaction as moderate. Eltrombopag and Ethinylestradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinylestradiol is a weak CYP1A2 inhibitor, and eltrombopag is partly cleared by CYP1A2. A small rise in eltrombopag exposure is possible. Estrogens also raise thrombotic risk, which adds to the thrombotic risk of eltrombopag.
How serious is the interaction between Eltrombopag and Ethinylestradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and liver tests. Consider non-estrogen contraception in patients with additional thrombotic risk factors.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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