Drug interactions
Eltrombopag + Fenoprofen
Severity: Minor
Eltrombopag and Fenoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT1A1 and other UGT enzymes in vitro, and fenoprofen is cleared in part by glucuronidation, so exposure could rise. A clinically meaningful effect has not been demonstrated.
What this interaction means in plain words
Eltrombopag and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Fenoprofen belongs to Musculoskeletal.
Why it happens
Possible inhibition of UGT-mediated glucuronidation of fenoprofen by eltrombopag, predicted from in vitro data.
What to do
No dose change is generally required; watch for increased NSAID adverse effects such as GI upset or renal changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Fenoprofen?
MediHelp rates the interaction as minor. Eltrombopag and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT1A1 and other UGT enzymes in vitro, and fenoprofen is cleared in part by glucuronidation, so exposure could rise. A clinically meaningful effect has not been demonstrated.
How serious is the interaction between Eltrombopag and Fenoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; watch for increased NSAID adverse effects such as GI upset or renal changes.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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