Drug interactions
Eltrombopag + Glecaprevir / pibrentasvir
Severity: Moderate
Eltrombopag and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir are substrates of OATP1B1 and BCRP, which eltrombopag inhibits. Exposure to the antivirals may increase, raising the risk of liver enzyme elevations.
What this interaction means in plain words
Eltrombopag and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Eltrombopag inhibits OATP1B1 and BCRP, reducing hepatic uptake and efflux of glecaprevir and pibrentasvir.
What to do
Monitor liver function tests and for antiviral adverse effects during coadministration. Watch closely for hepatic decompensation in patients with cirrhosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Eltrombopag and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir are substrates of OATP1B1 and BCRP, which eltrombopag inhibits. Exposure to the antivirals may increase, raising the risk of liver enzyme elevations.
How serious is the interaction between Eltrombopag and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for antiviral adverse effects during coadministration. Watch closely for hepatic decompensation in patients with cirrhosis.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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