Drug interactions
Eltrombopag + Ketorolac intranasal
Severity: Moderate
Eltrombopag and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is partly glucuronidated, and eltrombopag inhibits UGT enzymes in vitro, so exposure could rise, though the effect is unproven. Ketorolac also impairs platelet function and can cause GI bleeding and renal injury, which is a concern in thrombocytopenia.
What this interaction means in plain words
Eltrombopag and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible UGT inhibition by eltrombopag, plus additive bleeding risk from ketorolac's antiplatelet effect.
What to do
Avoid ketorolac in patients with significant thrombocytopenia and use a non-NSAID analgesic. If used, keep treatment short and monitor for bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Eltrombopag and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is partly glucuronidated, and eltrombopag inhibits UGT enzymes in vitro, so exposure could rise, though the effect is unproven. Ketorolac also impairs platelet function and can cause GI bleeding and renal injury, which is a concern in thrombocytopenia.
How serious is the interaction between Eltrombopag and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients with significant thrombocytopenia and use a non-NSAID analgesic. If used, keep treatment short and monitor for bleeding and renal function.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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