Drug interactions
Eltrombopag + Levorphanol
Severity: Minor
Eltrombopag and Levorphanol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is cleared by glucuronidation, and eltrombopag inhibits UGT enzymes in vitro. Opioid exposure might rise, though no clinical effect has been shown.
What this interaction means in plain words
Eltrombopag and Levorphanol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
In vitro UGT inhibition by eltrombopag may reduce levorphanol glucuronidation.
What to do
Monitor for sedation and respiratory depression when starting eltrombopag. Reduce the levorphanol dose if opioid effects increase.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Levorphanol?
MediHelp rates the interaction as minor. Eltrombopag and Levorphanol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levorphanol is cleared by glucuronidation, and eltrombopag inhibits UGT enzymes in vitro. Opioid exposure might rise, though no clinical effect has been shown.
How serious is the interaction between Eltrombopag and Levorphanol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression when starting eltrombopag. Reduce the levorphanol dose if opioid effects increase.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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