Drug interactions
Eltrombopag + Magnesium sulfate
Severity: Moderate
Eltrombopag and Magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium sulfate can chelate eltrombopag in the gut. Intravenous magnesium sulfate would not be expected to interact by this route.
What this interaction means in plain words
Eltrombopag and Magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium cations chelate eltrombopag in the gastrointestinal tract, reducing absorption.
What to do
For oral magnesium sulfate, give eltrombopag 2 hours before or 4 hours after. No separation is needed for intravenous use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Magnesium sulfate?
MediHelp rates the interaction as moderate. Eltrombopag and Magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium sulfate can chelate eltrombopag in the gut. Intravenous magnesium sulfate would not be expected to interact by this route.
How serious is the interaction between Eltrombopag and Magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For oral magnesium sulfate, give eltrombopag 2 hours before or 4 hours after. No separation is needed for intravenous use.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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