Drug interactions
Eltrombopag + Meclofenamate
Severity: Moderate
Eltrombopag and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is partly glucuronidated, and eltrombopag inhibits UGT enzymes in vitro, so its exposure might increase. NSAIDs also impair platelet function and can cause GI bleeding, which is important in thrombocytopenia.
What this interaction means in plain words
Eltrombopag and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible UGT inhibition by eltrombopag, plus additive bleeding risk from NSAID antiplatelet effects.
What to do
Prefer a non-NSAID analgesic in patients with low platelet counts. If an NSAID is necessary, monitor for bleeding and platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Meclofenamate?
MediHelp rates the interaction as moderate. Eltrombopag and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate is partly glucuronidated, and eltrombopag inhibits UGT enzymes in vitro, so its exposure might increase. NSAIDs also impair platelet function and can cause GI bleeding, which is important in thrombocytopenia.
How serious is the interaction between Eltrombopag and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic in patients with low platelet counts. If an NSAID is necessary, monitor for bleeding and platelet counts.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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