Drug interactions
Eltrombopag + Methotrexate
Severity: Moderate
Eltrombopag and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1 and BCRP transporters, which are involved in methotrexate disposition. Methotrexate exposure may therefore rise, increasing the risk of toxicity, although clinical data are limited.
What this interaction means in plain words
Eltrombopag and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Methotrexate belongs to Oncology.
Why it happens
Eltrombopag inhibits BCRP and OATP1B1 transporters, which may reduce methotrexate clearance.
What to do
Monitor for methotrexate toxicity including blood counts, liver enzymes and renal function. Consider methotrexate dose reduction if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Methotrexate?
MediHelp rates the interaction as moderate. Eltrombopag and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits OATP1B1 and BCRP transporters, which are involved in methotrexate disposition. Methotrexate exposure may therefore rise, increasing the risk of toxicity, although clinical data are limited.
How serious is the interaction between Eltrombopag and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for methotrexate toxicity including blood counts, liver enzymes and renal function. Consider methotrexate dose reduction if adverse effects emerge.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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