Drug interactions
Eltrombopag + Peginterferon alfa 2a
Severity: Moderate
Eltrombopag and Peginterferon alfa 2a: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag is used in hepatitis C patients to enable interferon therapy, and the two are commonly given together. Eltrombopag raises the risk of hepatic decompensation in chronic hepatitis C patients receiving interferon-based regimens, and CYP1A2 inhibition by peginterferon may modestly raise eltrombopag exposure.
What this interaction means in plain words
Eltrombopag and Peginterferon alfa 2a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Peginterferon alfa 2a belongs to Anti Virals.
Why it happens
Possible CYP1A2 inhibition by peginterferon; additive hepatotoxic risk is a pharmacodynamic concern.
What to do
Monitor liver function tests and platelet counts regularly. Stop therapy if hepatic decompensation or significant liver injury occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Peginterferon alfa 2a
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Peginterferon alfa 2a?
MediHelp rates the interaction as moderate. Eltrombopag and Peginterferon alfa 2a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag is used in hepatitis C patients to enable interferon therapy, and the two are commonly given together. Eltrombopag raises the risk of hepatic decompensation in chronic hepatitis C patients receiving interferon-based regimens, and CYP1A2 inhibition by peginterferon may modestly raise eltrombopag exposure.
How serious is the interaction between Eltrombopag and Peginterferon alfa 2a?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and platelet counts regularly. Stop therapy if hepatic decompensation or significant liver injury occurs.
What other medicines interact with Peginterferon alfa 2a?
MediHelp also lists interactions of Peginterferon alfa 2a with, for example, Clozapine, Deferiprone, Hydroxyurea. The full list is on the Peginterferon alfa 2a page.
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