Drug interactions
Eltrombopag + Phenobarbital
Severity: Moderate
Eltrombopag and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a potent enzyme inducer and may lower eltrombopag concentrations, potentially reducing platelet response.
What this interaction means in plain words
Eltrombopag and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenobarbital induction of CYP1A2, CYP2C8 and UGT enzymes may increase eltrombopag clearance.
What to do
Monitor platelet counts when phenobarbital is started, changed or stopped. Increase the eltrombopag dose if response falls, and reduce it if phenobarbital is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Phenobarbital?
MediHelp rates the interaction as moderate. Eltrombopag and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a potent enzyme inducer and may lower eltrombopag concentrations, potentially reducing platelet response.
How serious is the interaction between Eltrombopag and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts when phenobarbital is started, changed or stopped. Increase the eltrombopag dose if response falls, and reduce it if phenobarbital is withdrawn.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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