Drug interactions
Eltrombopag + Pitavastatin
Severity: Moderate
Eltrombopag and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1, a key hepatic uptake transporter for pitavastatin, and may raise pitavastatin exposure. This could increase the risk of myopathy.
What this interaction means in plain words
Eltrombopag and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Pitavastatin belongs to Cardiovascular.
Why it happens
Eltrombopag inhibits OATP1B1, reducing hepatic uptake of pitavastatin.
What to do
Use the lowest effective pitavastatin dose and monitor for muscle symptoms, checking CK if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Pitavastatin?
MediHelp rates the interaction as moderate. Eltrombopag and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits OATP1B1, a key hepatic uptake transporter for pitavastatin, and may raise pitavastatin exposure. This could increase the risk of myopathy.
How serious is the interaction between Eltrombopag and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pitavastatin dose and monitor for muscle symptoms, checking CK if they occur.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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