Drug interactions
Eltrombopag + Sacubitril / valsartan
Severity: Minor
Eltrombopag and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1, and valsartan is an OATP1B1 substrate, so valsartan exposure may be raised, increasing hypotension or hyperkalemia risk. The effect is expected to be modest.
What this interaction means in plain words
Eltrombopag and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Eltrombopag inhibits hepatic OATP1B1 uptake of valsartan, which may increase systemic exposure.
What to do
Monitor blood pressure, renal function and potassium when starting eltrombopag in patients on sacubitril/valsartan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Eltrombopag and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits OATP1B1, and valsartan is an OATP1B1 substrate, so valsartan exposure may be raised, increasing hypotension or hyperkalemia risk. The effect is expected to be modest.
How serious is the interaction between Eltrombopag and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium when starting eltrombopag in patients on sacubitril/valsartan.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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