Drug interactions
Eltrombopag + Salsalate
Severity: Minor
Eltrombopag and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag may inhibit UGT enzymes and modestly raise salicylate exposure from salsalate. The clinical impact is uncertain, but salicylates can increase bleeding risk in thrombocytopenic patients.
What this interaction means in plain words
Eltrombopag and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
In vitro UGT inhibition by eltrombopag may reduce glucuronidation of salicylate.
What to do
Monitor for salicylate toxicity and bleeding; consider an alternative analgesic if platelet counts are very low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Salsalate?
MediHelp rates the interaction as minor. Eltrombopag and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag may inhibit UGT enzymes and modestly raise salicylate exposure from salsalate. The clinical impact is uncertain, but salicylates can increase bleeding risk in thrombocytopenic patients.
How serious is the interaction between Eltrombopag and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for salicylate toxicity and bleeding; consider an alternative analgesic if platelet counts are very low.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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