Drug interactions
Eltrombopag + Sodium bicarbonate
Severity: Minor
Eltrombopag and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium bicarbonate contains no polyvalent cation, so chelation of eltrombopag is not expected. Any effect would be through altered gastric pH, which is not well documented for eltrombopag.
What this interaction means in plain words
Eltrombopag and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; possible minor effect of raised gastric pH.
What to do
No specific separation is required; monitor platelet counts as routinely done.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Eltrombopag with Sodium bicarbonate?
MediHelp rates the interaction as minor. Eltrombopag and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium bicarbonate contains no polyvalent cation, so chelation of eltrombopag is not expected. Any effect would be through altered gastric pH, which is not well documented for eltrombopag.
How serious is the interaction between Eltrombopag and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific separation is required; monitor platelet counts as routinely done.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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