Drug interactions
Eltrombopag + Sulfamethoxazole
Severity: Minor
Eltrombopag and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9, one pathway involved in eltrombopag metabolism, so eltrombopag exposure may rise slightly. The effect is likely small because eltrombopag has multiple clearance routes.
What this interaction means in plain words
Eltrombopag and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sulfamethoxazole inhibits CYP2C9, potentially reducing eltrombopag metabolism.
What to do
No routine adjustment; monitor platelet counts and liver tests during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Sulfamethoxazole?
MediHelp rates the interaction as minor. Eltrombopag and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole inhibits CYP2C9, one pathway involved in eltrombopag metabolism, so eltrombopag exposure may rise slightly. The effect is likely small because eltrombopag has multiple clearance routes.
How serious is the interaction between Eltrombopag and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor platelet counts and liver tests during co-therapy.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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