Drug interactions
Eltrombopag + Sulfasalazine
Severity: Minor
Eltrombopag and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes and BCRP in vitro, so sulfasalazine exposure may increase. Clinical significance is unclear.
What this interaction means in plain words
Eltrombopag and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Eltrombopag inhibits BCRP and UGT, which may reduce sulfasalazine clearance.
What to do
Monitor for sulfasalazine adverse effects such as GI intolerance and blood count changes; no routine dose change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Sulfasalazine?
MediHelp rates the interaction as minor. Eltrombopag and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes and BCRP in vitro, so sulfasalazine exposure may increase. Clinical significance is unclear.
How serious is the interaction between Eltrombopag and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects such as GI intolerance and blood count changes; no routine dose change.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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