Drug interactions
Elvitegravir + Imatinib
Severity: Minor
Elvitegravir and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir is a CYP3A4 substrate and is normally given with a booster. Imatinib could increase its levels, but the effect is probably small relative to boosting.
What this interaction means in plain words
Elvitegravir and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Imatinib inhibits CYP3A4, slightly reducing elvitegravir metabolism.
What to do
No dose change is generally needed; monitor for adverse effects. Be aware that the cobicistat or ritonavir booster also raises imatinib levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Elvitegravir with Imatinib?
MediHelp rates the interaction as minor. Elvitegravir and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir is a CYP3A4 substrate and is normally given with a booster. Imatinib could increase its levels, but the effect is probably small relative to boosting.
How serious is the interaction between Elvitegravir and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for adverse effects. Be aware that the cobicistat or ritonavir booster also raises imatinib levels.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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