Drug interactions
Elvitegravir + Naloxone
Severity: Minor
Elvitegravir and Naloxone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pharmacokinetic data with buprenorphine/naloxone and elvitegravir regimens showed no clinically meaningful change requiring dose adjustment. Naloxone has minimal oral bioavailability, so any change in exposure is of little consequence.
What this interaction means in plain words
Elvitegravir and Naloxone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; a small change in naloxone exposure has been observed.
What to do
No dose adjustment is needed. Monitor for sedation or reduced opioid effect if used with buprenorphine/naloxone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naloxone
- Naldemedine + Naloxone Moderate
- Naloxegol + Naloxone Moderate
Frequently asked questions
Can I take Elvitegravir with Naloxone?
MediHelp rates the interaction as minor. Elvitegravir and Naloxone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pharmacokinetic data with buprenorphine/naloxone and elvitegravir regimens showed no clinically meaningful change requiring dose adjustment. Naloxone has minimal oral bioavailability, so any change in exposure is of little consequence.
How serious is the interaction between Elvitegravir and Naloxone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for sedation or reduced opioid effect if used with buprenorphine/naloxone.
What other medicines interact with Naloxone?
MediHelp also lists interactions of Naloxone with, for example, Naldemedine, Naloxegol. The full list is on the Naloxone page.
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