Drug interactions
Naloxegol + Naloxone
Severity: Moderate
Naloxegol and Naloxone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block opioid receptors, and combined use may add to antagonism and raise the chance of opioid withdrawal symptoms in opioid-dependent patients. Naloxegol is peripherally restricted but can still cause withdrawal if the barrier is compromised.
What this interaction means in plain words
Naloxegol and Naloxone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naloxegol belongs to Gastrointestinal Tract; Naloxone belongs to Musculoskeletal.
Why it happens
Additive opioid receptor antagonism.
What to do
Give naloxone for overdose when indicated and monitor for withdrawal and loss of analgesia. Do not use additional antagonists routinely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naloxone
- Naldemedine + Naloxone Moderate
- Elvitegravir + Naloxone Minor
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Naloxegol with Naloxone?
MediHelp rates the interaction as moderate. Naloxegol and Naloxone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents block opioid receptors, and combined use may add to antagonism and raise the chance of opioid withdrawal symptoms in opioid-dependent patients. Naloxegol is peripherally restricted but can still cause withdrawal if the barrier is compromised.
How serious is the interaction between Naloxegol and Naloxone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give naloxone for overdose when indicated and monitor for withdrawal and loss of analgesia. Do not use additional antagonists routinely.
What other medicines interact with Naloxone?
MediHelp also lists interactions of Naloxone with, for example, Naldemedine, Elvitegravir. The full list is on the Naloxone page.
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