Drug interactions
Naldemedine + Naloxone
Severity: Moderate
Naldemedine and Naloxone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are opioid antagonists, so using them together adds antagonism at opioid receptors. In patients taking opioids this could precipitate withdrawal, though naloxone is often given for emergencies and absorption by non-parenteral routes is low.
What this interaction means in plain words
Naldemedine and Naloxone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naldemedine belongs to Gastrointestinal Tract; Naloxone belongs to Musculoskeletal.
Why it happens
Additive opioid receptor antagonism.
What to do
Use naloxone when clinically needed for overdose despite naldemedine and monitor for withdrawal symptoms. Avoid routine concurrent use of other opioid antagonists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naloxone
- Naloxegol + Naloxone Moderate
- Elvitegravir + Naloxone Minor
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Naloxone?
MediHelp rates the interaction as moderate. Naldemedine and Naloxone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are opioid antagonists, so using them together adds antagonism at opioid receptors. In patients taking opioids this could precipitate withdrawal, though naloxone is often given for emergencies and absorption by non-parenteral routes is low.
How serious is the interaction between Naldemedine and Naloxone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use naloxone when clinically needed for overdose despite naldemedine and monitor for withdrawal symptoms. Avoid routine concurrent use of other opioid antagonists.
What other medicines interact with Naloxone?
MediHelp also lists interactions of Naloxone with, for example, Naloxegol, Elvitegravir. The full list is on the Naloxone page.
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