Drug interactions
Elvitegravir + Nicardipine
Severity: Minor
Elvitegravir and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir is a CYP3A4 substrate, but it is given with cobicistat, a potent booster. Nicardipine's weaker CYP3A4 inhibition is unlikely to change elvitegravir exposure meaningfully, while cobicistat may raise nicardipine levels.
What this interaction means in plain words
Elvitegravir and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nicardipine may weakly inhibit CYP3A4, but cobicistat's boosting dominates elvitegravir kinetics.
What to do
No elvitegravir adjustment is needed; monitor blood pressure and heart rate because cobicistat may raise nicardipine exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Elvitegravir with Nicardipine?
MediHelp rates the interaction as minor. Elvitegravir and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir is a CYP3A4 substrate, but it is given with cobicistat, a potent booster. Nicardipine's weaker CYP3A4 inhibition is unlikely to change elvitegravir exposure meaningfully, while cobicistat may raise nicardipine levels.
How serious is the interaction between Elvitegravir and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No elvitegravir adjustment is needed; monitor blood pressure and heart rate because cobicistat may raise nicardipine exposure.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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