Drug interactions
Elvitegravir + Warfarin
Severity: Moderate
Elvitegravir and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir is given with cobicistat, a CYP3A inhibitor, in many regimens, and it is itself a weak CYP2C9 inducer. Effects on warfarin are unpredictable, and INR may change in either direction after the start or end of therapy.
What this interaction means in plain words
Elvitegravir and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible modest CYP2C9 induction by elvitegravir; the effect of the boosted regimen on warfarin is not well established.
What to do
Monitor INR closely when starting or stopping the antiretroviral regimen. Adjust the warfarin dose according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elvitegravir and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Elvitegravir with Warfarin?
MediHelp rates the interaction as moderate. Elvitegravir and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elvitegravir is given with cobicistat, a CYP3A inhibitor, in many regimens, and it is itself a weak CYP2C9 inducer. Effects on warfarin are unpredictable, and INR may change in either direction after the start or end of therapy.
How serious is the interaction between Elvitegravir and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely when starting or stopping the antiretroviral regimen. Adjust the warfarin dose according to results.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
