Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eszopiclone
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor, and it raises eszopiclone concentrations. This may lead to greater sedation, next-day impairment and complex sleep behaviors.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4-mediated metabolism of eszopiclone.
What to do
Start eszopiclone at 1 mg, do not exceed 2 mg, and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Eszopiclone?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor, and it raises eszopiclone concentrations. This may lead to greater sedation, next-day impairment and complex sleep behaviors.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at 1 mg, do not exceed 2 mg, and monitor for oversedation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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